Key result
Insulin resistance was positively correlated with triglycerides (r=0.30, P<0.01) and negatively correlated with HDL (r=-0.38, P<0.001), whereas lipoprotein particles did not correlate with OSA severity.
Why the study?
Are pro-atherogenic lipoprotein abnormalities in obstructive sleep apnea related to insulin resistance or OSA severity?
Cross-Sectional (n=107)
No
Are pro-atherogenic lipoprotein abnormalities in obstructive sleep apnea related to insulin resistance or OSA severity?
Pro-atherogenic lipoprotein abnormalities in obstructive sleep apnea are related to insulin resistance rather than OSA severity or degree of hypoxia.
May link insulin resistance to dyslipidemia in OSA independently of severity; leaves open causal inference and intervention effects.
STUDY OBJECTIVE: Prevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia in these individuals. Insulin resistance is also common in OSA, but its contribution to dyslipidemia of OSA is unclear. The study's aim was to define the relationships among abnormalities of lipoprotein metabolism, clinical measures of OSA, and insulin resistance. DESIGN: Cross-sectional study. OSA severity was defined by the apnea-hypopnea index (AHI) during polysomnography. Hypoxia measures were expressed as minimum and mean oxygen saturation, and the oxygen desaturation index. Insulin resistance was quantified by determining steady-state plasma glucose (SSPG) concentrations during the insulin suppression test. Fasting plasma lipid/lipoprotein evaluation was performed by vertical auto profile methodology. SETTING: Academic medical center. PARTICIPANTS: 107 nondiabetic, overweight/obese adults. MEASUREMENTS AND RESULTS: Lipoprotein particles did not correlate with AHI or any hypoxia measures, nor were there differences noted by categories of OSA severity. By contrast, even after adjustment for age, sex, and BMI, SSPG was positively correlated with triglycerides (r = 0.30, P < 0.01), very low density lipoprotein (VLDL) and its subclasses (VLDL1+2) (r = 0.21-0.23, P < 0.05), and low density lipoprotein subclass 4 (LDL4) (r = 0.30, P < 0.01). SSPG was negatively correlated with high density lipoprotein (HDL) (r = -0.38, P < 0.001) and its subclasses (HDL2 and HDL3) (r = -0.32, -0.43, P < 0.01), and apolipoprotein A1 (r = -0.33, P < 0.01). Linear trends of these lipoprotein concentrations across SSPG tertiles were also significant. CONCLUSIONS: Pro-atherogenic lipoprotein abnormalities in obstructive sleep apnea (OSA) are related to insulin resistance, but not to OSA severity or degree of hypoxia. Insulin resistance may represent the link between OSA-related dyslipidemia and increased cardiovascular disease risk.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2015) conducted a cross-sectional in Obstructive sleep apnea (n=107). Insulin resistance (steady-state plasma glucose) vs. OSA severity (apnea-hypopnea index) was evaluated on Relationships among abnormalities of lipoprotein metabolism, clinical measures of OSA, and insulin resistance. Insulin resistance was positively correlated with triglycerides (r=0.30, P<0.01) and negatively correlated with HDL (r=-0.38, P<0.001), whereas lipoprotein particles did not correlate with OSA severity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: