Hyposalivation Treatment with Non-Crosslinked Hyaluronic Acid and Amino Acids Solution—A Clinical Pilot Study

Background. This randomized controlled clinical study aimed to evaluate changes in salivary secretion following injections of a hyaluronic acid and amino acid solution in patients with hyposalivation. Materials and Methods. A total of 100 patients with symptoms of hyposalivation were randomly assigned to either a study group or a control group (1:1). The consistency and pH of unstimulated saliva, as well as the volume and buffering capacity of stimulated saliva, were assessed using the Saliva-Check Buffer GC test at baseline and after the study period. Patients in the study group received injections of a hyaluronic acid and amino acid solution into the buccal mucosa in four sessions at two-week intervals, while the control group received no intervention. Results: Significant improvements were observed in the intervention group, including favorable changes in the consistency and pH of unstimulated saliva as well as increases in the volume and buffering capacity of stimulated saliva over the study period. A paired t-test demonstrated a significant increase in salivary pH following treatment (t = −10.07, p < 0.001). The mean pH increased from 6.54 (95% CI: 6.42–6.65) at baseline to 7.31 (95% CI: 7.22–7.40) after the intervention, representing a mean increase of 0.78 units (95% CI: 0.62–0.93). Additionally, the Wilcoxon signed-rank test revealed a significant improvement in stimulated salivary flow (V = 1275, p < 0.001). The median salivary volume increased from 1.5 mL at baseline to 5.0 mL post-treatment, representing a median increase of 3.75 mL (95% CI: 3.5–4.0). No statistically significant changes were observed in the control group for saliva pH, consistency, or buffering capacity. Stimulated salivary flow showed a statistically significant difference (p = 0.002) but with a median increase of 0 mL, indicating no clinically meaningful change. Conclusions: Injections of a hyaluronic acid and amino acid solution may represent a promising therapeutic option for patients with symptoms of dry mouth. Study registered on Clinicaltrials NCT07309588.