Key result
Interatrial septum pacing in AAIR mode combined with antiarrhythmic drug therapy significantly prolonged the arrhythmia-free interval compared to the pre-implantation period (38.7 vs 24.1 days; P<0.05).
Why the study?
Does interatrial septum pacing combined with antiarrhythmic drugs improve the arrhythmia free interval in patients with drug refractory paroxysmal atrial fibrillation and prolonged inter-atrial conduction time?
Population
29 patients with drug refractory paroxysmal atrial fibrillation, normal sinus node function and prolonged…
Comparison
Interatrial septum pacing guided by pace… vs Pre-implantation period under antiarrhythmic…
Design
RCT, Random selection of the order for AAT and AAIR pacing modes
Follow-up
Four periods of 3 months duration each (12 months total)
Authors
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Hypothesis-generating for interatrial septum pacing in refractory paroxysmal AF; randomized trials needed before practice change.
RCT (n=29)
Randomized crossover
Does interatrial septum pacing combined with antiarrhythmic drugs improve the arrhythmia free interval in patients with drug refractory paroxysmal atrial fibrillation and prolonged inter-atrial conduction time?
Absolute Event Rate: 38.7% vs 24.1%
p-value: p=<0.05
Antonis S. Manolis (2002) conducted an RCT in Drug refractory paroxysmal atrial fibrillation (n=29). Interatrial septum (IAS) pacing vs. Pre-implantation period (antiarrhythmic treatment only) was evaluated on Arrhythmia free interval (p=<0.05). Interatrial septum pacing in AAIR mode combined with antiarrhythmic drug therapy significantly prolonged the arrhythmia-free interval compared to the pre-implantation period (38.7 vs 24.1 days; P<0.05).
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