Key result
Hypertensive patients with abnormal diurnal blood pressure variation patterns had significantly higher plasma BNP levels (16.8 pg/mL) compared to those with normal circadian variation (8.4 pg/mL).
Why the study?
Does an abnormal diurnal blood pressure variation profile associate with elevated plasma BNP levels in asymptomatic hypertensive patients?
Cross-Sectional (n=98)
No
Does an abnormal diurnal blood pressure variation profile associate with elevated plasma BNP levels in asymptomatic hypertensive patients?
Absolute Event Rate: 16.8% vs 8.4%
p-value: p=<0.01
Plasma BNP levels are significantly elevated in asymptomatic hypertensive patients with abnormal diurnal blood pressure variation, suggesting its utility as a biomarker for identifying patients at higher cardiovascular risk.
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Abnormal BP variation associated with higher BNP; hypothesis-generating for BNP as risk biomarker, should not yet change practice.
Nakatsu et al. (2007) conducted a cross-sectional in Asymptomatic essential hypertension (n=98). Abnormal diurnal BP variation (nondippers, extreme dippers, risers) vs. Normal diurnal BP variation (dippers) was evaluated on Plasma BNP level (pg/mL) (p=<0.01). Hypertensive patients with abnormal diurnal blood pressure variation patterns had significantly higher plasma BNP levels (16.8 pg/mL) compared to those with normal circadian variation (8.4 pg/mL).
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