Key result
Hypertensive patients with abnormal diastolic function (E/A ratio < 1) had significantly higher median plasma BNP concentrations than those with normal function (12.9 vs 5.9 pmol/L; P=0.006).
Population
32 patients with newly diagnosed untreated mild-to-moderate hypertension
Design
Cross-sectional
Authors
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BNP may mark diastolic dysfunction in untreated hypertension; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=32)
Absolute Event Rate: 12.9% vs 5.9%
p-value: p=0.006
Plasma BNP levels correlate with diastolic dysfunction in patients with newly diagnosed, untreated hypertension, independent of age and blood pressure.
Bernard MY Cheung (1997) conducted a cross-sectional in newly diagnosed untreated mild-to-moderate hypertension (n=32). Abnormal Doppler transmitral flow (E/A ratio < 1) vs. Normal Doppler transmitral flow (E/A ≥ 1) was evaluated on Median plasma BNP concentration (pmol/L) (p=0.006). Hypertensive patients with abnormal diastolic function (E/A ratio < 1) had significantly higher median plasma BNP concentrations than those with normal function (12.9 vs 5.9 pmol/L; P=0.006).
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