What question did this study set out to answer?

To evaluate the relationship between essential hypertension and plasma concentrations of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to assess whether these two peptides correlate.

April 1, 1994Journal of Hypertension

Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension

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Why the study?

Are plasma levels of BNP and CNP elevated in patients with essential hypertension compared to normotensive controls?

Population

54 subjects, with a subgroup of 19 hypertensive patients paired with 19 normotensive controls matched for…

Design

Cross-sectional

Authors

BCBernard M.Y. CheungPreventive Cardiology MBMorris J. BrownPreventive Cardiology

Discussion

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Implication

BNP may mark cardiac strain in hypertension; cross-sectional data leave open causal roles or CNP relevance.

Key Points

To evaluate the relationship between essential hypertension and plasma concentrations of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to assess whether these two peptides correlate.
Conducted a cross-sectional study of 54 participants (29 hypertensive, 25 normotensive controls), including a primary matched subgroup of 19 age- and sex-paired hypertensive-control couples.
Determined circulating plasma levels of BNP and CNP using specific radioimmunoassays.
Performed multiple regression analyses across all 54 subjects to evaluate associations with age, sex, blood pressure, heart rate, and alcohol intake.
Mean plasma BNP concentration was significantly higher in hypertensive patients than in matched normotensive controls and correlated significantly with age and systolic blood pressure.
Mean plasma CNP concentration did not differ significantly between hypertensive patients and matched controls and did not correlate with systolic blood pressure, diastolic blood pressure, or BNP.
Plasma CNP levels correlated significantly with sex, heart rate, and alcohol intake across the full cohort.

Structured PICO

Are plasma levels of BNP and CNP elevated in patients with essential hypertension compared to normotensive controls?

Population

54 subjects (29 hypertensive patients, 25 normotensive controls), with a subgroup of 19 hypertensive patients paired with 19 normotensive controls matched for age and sex.

Comparator

Normotensive controls matched for age and sex

Outcome

Plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP)surrogate

Essential hypertension is associated with elevated plasma levels of BNP but not CNP.

Cite This Study

Cheung et al. (1994) studied this question.

synapsesocial.com/papers/6a7db481cecc27a187a14710 https://doi.org/10.1097/00004872-199404000-00015

Topics

Hypertension management

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Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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