Key result
A one standard deviation increase in baseline log-transformed NT-proBNP concentrations was associated with a 14% lower risk of incident hypertension over 5 years.
Why the study?
Does higher serum NT-proBNP associate with prevalent and incident hypertension in a general population sample?
Cohort (n=5,307)
No
Does higher serum NT-proBNP associate with prevalent and incident hypertension in a general population sample?
Answers are grounded in this paper and cite their sources.
Higher serum NT-proBNP concentrations are associated with prevalent hypertension, whereas lower concentrations predict incident hypertension, suggesting a potential causal role for reduced BNP in early hypertension pathogenesis.
BACKGROUND: The role of the natriuretic peptides (NPs) in hypertension is complex. Thus, a higher blood NP concentration is a robust marker of pressure-induced cardiac damage in patients with hypertension, whereas genetically elevated NP concentrations are associated with a reduced risk of hypertension and overweight individuals presumably at high risk of hypertension have lower NP concentrations. OBJECTIVE: To investigate the associations between serum N-terminal pro-B-type natriuretic peptide (NT-proBNP), used as a surrogate marker for active BNP, and prevalent as well as 5-year incident hypertension in a Danish general population sample. METHODS: Cross-sectional and prospective population-based study. RESULTS: At baseline, among 5,307 participants (51.3% women, mean age 46.0±7.9 years) with a complete set of data, we recorded 1,979 cases with prevalent hypertension (PHT). Among 2,389 normotensive participants at baseline with a complete set of data, we recorded 324 cases with incident hypertension (IHT) on follow-up 5 years later. In models adjusted for age, sex, lifestyle, social, dietary, anthropometric, pulmonic, lipid, metabolic and renal risk factors, as well as heart rate and baseline blood pressure (only incident model), one standard deviation increase in baseline log-transformed NT-proBNP concentrations was on one side associated with a 21% higher risk of PHT (odds ratio [OR]: 1.21 [95% confidence interval (CI): 1.13-1.30], P<0.001), and on the other side with a 14% lower risk of IHT (OR: 0.86 [95%CI:0.76-0.98], P = 0.020). CONCLUSIONS: Higher serum concentrations of NT-proBNP associate with PHT whereas lower concentrations associate with IHT. This suggests that a lower amount of circulating BNP, resulting in diminished vasodilation and natriuresis, could be involved in the pathogenesis of hypertension in its early stages.
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Seven et al. (2015) conducted a cohort in Hypertension (n=5,307). NT-proBNP (per 1 SD increase in log-transformed concentration) was evaluated on Incident hypertension at 5 years (OR 0.86, 95% CI 0.76-0.98, p=0.020). A one standard deviation increase in baseline log-transformed NT-proBNP concentrations was associated with a 14% lower risk of incident hypertension over 5 years.
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