Key result
Antihypertensive drug therapy was continuously maintained for 10 years by only 39% of patients, with higher persistence for ACE inhibitors (OR 0.38; 95% CI 0.27-0.55) compared to diuretics.
Why the study?
What is the rate and what are the determinants of 10-year persistence with antihypertensive drugs in newly treated patients?
Population
2,325 patients who started using antihypertensive drugs in 1992 and did not receive a prescription for any…
Design
Cohort
Follow-up
10 years
Authors
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Low 10-year persistence signals adherence gaps; leaves open whether ACE inhibitor preference improves outcomes in real-world cohorts.
Cohort (n=2,325)
Yes
What is the rate and what are the determinants of 10-year persistence with antihypertensive drugs in newly treated patients?
Long-term persistence with antihypertensive therapy in real-world practice is low (39% at 10 years), suggesting that drug class and prescriber type significantly influence long-term adherence.
Wijk et al. (2005) conducted a cohort in Hypertension (n=2,325). Antihypertensive drugs was evaluated on Persistence with antihypertensive drugs until 10 years. Antihypertensive drug therapy was continuously maintained for 10 years by only 39% of patients, with higher persistence for ACE inhibitors (OR 0.38; 95% CI 0.27-0.55) compared to diuretics.
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