Key result
ARBs achieve the lowest 4-year discontinuation rate among antihypertensives at ~58%.
Why the study?
Blood pressure control rates remain unsatisfactory despite widespread diagnosis and treatment of hypertension, with unclear reasons for poor long-term persistence with antihypertensive therapies in primary care.
Population
109,454 newly diagnosed hypertensive patients in the UK
Comparison
Persistence with different initial antihypertensive drug classes
Design
Observational analysis of prescription refill data from UK General Practice Research Database
Follow-up
Up to 9 years
Authors
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Antihypertensive persistence varies by class; observational data leaves open whether ARBs improve long-term control over diuretics.
Waeber et al. (2006) conducted an editorial in hypertension (n=109,454). Antihypertensive drug classes vs. Different antihypertensive classes was evaluated on cumulative incidence of discontinuation over the first 4 years of follow-up. Among newly diagnosed hypertensive patients, the 4-year cumulative incidence of discontinuation was lowest for AT1-receptor blockers (57.8%) and highest for thiazide diuretics (69.3%).
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