Key result
Primary human embryonic kidney cultures were superior for recovering polio, coxsackie B, adeno, and myxoviruses, while WI-38 cultures were superior for rhinoviruses, herpesviruses, and echoviruses.
Population
18,000 respiratory and 14,500 fecal specimens from index persons in the Seattle Virus Watch.
Comparison
Virus isolation using different cell cultures. vs Comparison among the different cell culture types.
Design
Cohort
Authors
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Multiple cell lines may be needed for complete viral isolation; supports and extends New York Virus Watch observations.
Observational
No
Different cell culture types have distinct sensitivities for isolating various respiratory and enteric viruses, necessitating multiple culture types for comprehensive viral screening.
Cooney et al. (1972) conducted an observational in Viral infections. Cell culture isolation methods (HEK and WI-38) was evaluated on Virus isolation rates. Primary human embryonic kidney cultures were superior for recovering polio, coxsackie B, adeno, and myxoviruses, while WI-38 cultures were superior for rhinoviruses, herpesviruses, and echoviruses.
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