Why the study?
Do alpha-sympathomimetic amines restore excitability and contractility via slow inward calcium current in guinea-pig ventricular muscle?
Do alpha-sympathomimetic amines restore excitability and contractility via slow inward calcium current in guinea-pig ventricular muscle?
The positive inotropic effect of alpha-adrenoceptor stimulation in guinea-pig ventricular muscle does not involve an increase in slow inward calcium current.
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Alpha-adrenoceptor inotropy independent of slow Ca current in guinea-pig ventricle; leaves open mechanisms in other species or human myocardium.
Ledda et al. (1980) studied this question.
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