Key result
Amrinone increases myocardial contractility in a concentration-dependent manner by enhancing slow calcium inward current.
Why the study?
The electromechanical effects of amrinone on isolated guinea pig ventricular muscle at various frequencies and conditions were not fully characterized.
Population
Isolated guinea pig papillary ventricular muscle
Comparison
Amrinone at concentrations 3 X 10(-5)-2 X 10(-3)M vs baseline conditions
Design
Preclinical experimental study using isolated muscle and voltage clamp techniques
Authors
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Amrinone's frequency-dependent inotropy in guinea pig muscle is hypothesis-generating; leaves open relevance to human HF dosing.
Amrinone's positive inotropic effect in ventricular muscle is primarily mediated by an increase in the slow inward calcium current.
Kondo et al. (1983) studied this question. Amrinone was evaluated on Electromechanical effects (positive inotropic effect, action potential duration, slow inward current). Amrinone caused a concentration-dependent positive inotropic effect and increased the slow calcium inward current in isolated guinea pig papillary muscles.
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