Population
Demembranated preparations of rat ventricular myocardium
Comparison
Amrinone vs Control conditions
Design
Preclinical
Authors
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May caution amrinone use in impaired contractility; leaves open translation from rat myofilaments to clinical HF.
Amrinone directly depresses ATP splitting and force generation in the myofilament system of rat cardiac muscle.
Mörner et al. (1992) studied this question.
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