Key result
Amrinone significantly enhanced maximum tetanic force (P<0.001) and depressed the velocity of unloaded shortening by 33 +/- 2% in isolated frog muscle fibres.
p-value: p=<0.001
Amrinone alters the contractile properties of frog striated muscle fibres through enhanced calcium release and direct effects on myosin cross-bridge kinetics.
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Amrinone's effects in frog fibres extend mechanistic insights into contractile modulation; leaves open relevance to mammalian cardiac muscle.
Månsson et al. (1985) studied Isolated single muscle fibres of the frog (n=6). Amrinone was evaluated on Maximum tetanic force and velocity of unloaded shortening (p=<0.001). Amrinone significantly enhanced maximum tetanic force (P<0.001) and depressed the velocity of unloaded shortening by 33 +/- 2% in isolated frog muscle fibres.
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