Why the study?
Does amrinone improve isometric force and alter action potentials in papillary muscles from guinea-pig hearts?
Population
Papillary muscles from guinea-pig hearts
Comparison
Amrinone (1 mM) vs Control (baseline before addition of the drug)
Design
Preclinical
Authors
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Amrinone augments twitch force in guinea-pig muscle; leaves open applicability to human myocardium.
Does amrinone improve isometric force and alter action potentials in papillary muscles from guinea-pig hearts?
Amrinone exerts positive inotropic effects in guinea-pig papillary muscles by increasing peak twitch force and rate of force rise while shortening relaxation time.
Mörner et al. (1990) studied this question.
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