Why the study?
Does amrinone alter transmembrane electrical activity in isolated mammalian cardiac tissue?
Population
Isolated normal and physiologically compromised mammalian cardiac Purkinje and ventricular tissues
Comparison
Amrinone at concentrations ranging from 10 to… vs Control conditions (absence of amrinone)
Design
Preclinical
Authors
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Hypothesis-generating for amrinone's electrophysiological actions; leaves open translation to human contractility or safety.
Does amrinone alter transmembrane electrical activity in isolated mammalian cardiac tissue?
In vitro, amrinone facilitates slow channel action potentials in mammalian cardiac tissue without arrhythmogenic effects, suggesting a mechanism for altering cardiac contractility and conduction.
Piwonka et al. (1983) studied this question.
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