Why the study?
Does amrinone affect atrioventricular conduction and sinoatrial nodal activity in the intact canine heart?
Population
Intact canine heart model
Comparison
Amrinone (2.5 to 10 mg/kg) vs Baseline and hearts with AV conduction depressed…
Design
Preclinical
Authors
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Hypothesis-generating for amrinone in canine AV conduction; leaves open human translation or clinical relevance.
Does amrinone affect atrioventricular conduction and sinoatrial nodal activity in the intact canine heart?
In a canine model, amrinone enhances AV conduction and SA nodal activity, and can partially reverse conduction depression induced by other cardioactive agents.
Nusrat et al. (1983) studied this question.
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