Electrophysiological Actions of Amrinone in Dogs with Cardiac Lesions

Dogs with cardiac lesions across five models (24-h post-coronary artery ligation arrhythmias, 2- to 6-day-old ischemic lesions, acute occlusion of the left anterior descending coronary artery followed by reperfusion, ouabain-intoxicated, and atrial circus flutter arrhythmia).

Intravenous amrinone at various doses (1.0, 1.5, 2.3, 3.0, and 6.0 mg/kg) depending on the experimental model.

Control dogs (specified in the acute occlusion/reperfusion model, n=15).

Arrhythmogenic or antiarrhythmic properties (incidence and severity of arrhythmias, fibrillation, and heart rate changes).surrogate