Key result
Amrinone acts preferentially as a coronary vasodilator rather than an inotrope compared to dobutamine.
Why the study?
The relative magnitude of the positive inotropic, chronotropic, and coronary vasodilating effects of amrinone compared with dobutamine was not well characterized in the canine heart-lung preparation.
Answers are grounded in this paper and cite their sources.
Analysis of the relative magnitude of the positive inotropic and chronotropic effects and the coronary vasodilating effects of amrinone conducted in the canine heart-lung preparation with a support dog in comparison with those of dobutamine demonstrated that amrinone was a preferential coronary vasodilator rather than a selective positive inotropic agent. An in vitro experiment in the canine papillary muscle suggested the initiation of the slow response action potential as a mechanism of the positive inotropic effect of amrinone.
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Takeda et al. (1986) studied this question. Amrinone vs. Dobutamine was evaluated on Relative magnitude of positive inotropic, chronotropic, and coronary vasodilating effects. Amrinone was demonstrated to be a preferential coronary vasodilator rather than a selective positive inotropic agent compared to dobutamine in a canine heart-lung preparation.
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