What question did this study set out to answer?

To assess whether amrinone, a positive inotropic-vasodilator agent, can reverse acute cardiac depression induced by various cardiotoxic drugs in anaesthetised dogs.

August 1, 1985Cardiovascular Research

The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog

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Why the study?

Does amrinone improve cardiac function in anaesthetised dogs with acute drug-induced heart failure?

Population

Anaesthetised dogs with acute drug-induced heart failure

Design

Preclinical

Authors

AAAdawia A. AlousiPacific University JCJay M. CanterSterling Research Group (United States)DFDorothy J. FortSterling Research Group (United States)

Discussion

Member takes

Implication

Does not support clinical use; extends preclinical evidence in canine models but leaves open human translation.

Key Points

To assess whether amrinone, a positive inotropic-vasodilator agent, can reverse acute cardiac depression induced by various cardiotoxic drugs in anaesthetised dogs.
Induced acute heart failure in anaesthetised dogs using bolus or infusion administrations of propranolol, verapamil, procainamide, or sodium pentobarbital.
Administered intravenous amrinone as a bolus (1 or 3 mg/kg) followed by continuous infusion (0.03 or 0.1 mg/kg/min) and evaluated hemodynamic responses compared with ouabain.
Drug administration induced severe cardiac depression characterized by a >40% decrease in contractile force and LV dp/dtmax, a 30% to 50% drop in cardiac output, and marked increases in CVP and RAP.
Amrinone reversed cardiac failure across all four drug models by increasing contractile force, cardiac output, and LV dp/dtmax while reducing preload (CVP or RAP) and total peripheral resistance.
Ouabain (40 µg/kg iv) increased total peripheral resistance with little restorative effect on contractile force or cardiac output in propranolol-induced heart failure, whereas amrinone remained effective.

Structured PICO

Does amrinone improve cardiac function in anaesthetised dogs with acute drug-induced heart failure?

Population

Anaesthetised dogs with acute drug-induced heart failure (induced by propranolol, verapamil, procainamide, or sodium pentobarbital)

Intervention

Amrinone administered intravenously as a bolus injection (1 or 3 mg/kg) plus an infusion (0.03 or 0.1 mg/kg/min)

Outcome

Cardiac function parameters including cardiac contractile force (CF), maximum left ventricular pressure development (LV dp/dtmax), cardiac output (CO), and central venous or right atrial blood pressuressurrogate

Amrinone effectively reverses severe cardiac depression in canine models of acute drug-induced heart failure.

Cite This Study

Alousi et al. (1985) studied this question.

synapsesocial.com/papers/6a7156115671bbf00bc2df42 https://doi.org/10.1093/cvr/19.8.483

Topics

Heart failure HFrEF treatment

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The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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