November 1, 1983British Journal of PharmacologyOpen Access

Effects of amrinone on the transmembrane action potential of rabbit sinus node pacemaker cells

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Why the study?

Does amrinone affect the membrane action potential and spontaneous activity in rabbit sinus node pacemaker cells?

Population

Rabbit sinus node pacemaker cells

Design

Preclinical

Authors

IKItsuo KodamaTokyo Institute of Technology NKNoriaki KondoShiga University SSShoji ShibataUniversity of Southern California

Discussion

Member takes

Implication

Amrinone may enhance rabbit sinus node automaticity via calcium currents; hypothesis-generating and should not change clinical practice.

Structured PICO

Does amrinone affect the membrane action potential and spontaneous activity in rabbit sinus node pacemaker cells?

Population

Rabbit sinus node pacemaker cells

Intervention

Amrinone (1 X 10(-4) M to 6 X 10(-6) M)

Outcome

Membrane action potential and spontaneous activity (cycle length of spontaneous firing, maximum upstroke velocity, amplitude of action potential, maximum diastolic potential)surrogate

Amrinone increases spontaneous firing activity in rabbit sinus node pacemaker cells, likely via augmentation of slow calcium and/or sodium inward currents.

Cite This Study

Kodama et al. (1983) studied this question.

synapsesocial.com/papers/6a8a7aec0f137e402b339068 https://doi.org/10.1111/j.1476-5381.1983.tb10723.x

View Full Paper

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Effects of amrinone on the transmembrane action potential of rabbit sinus node pacemaker cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of amrinone on the transmembrane action potential of rabbit sinus node pacemaker cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider