Why the study?
Does vinblastine, bleomycin, and cisplatin (VBP) combination chemotherapy cause vascular toxicity in patients with germ cell tumours?
Does vinblastine, bleomycin, and cisplatin (VBP) combination chemotherapy cause vascular toxicity in patients with germ cell tumours?
Combination chemotherapy with vinblastine, bleomycin, and cisplatin for germ cell tumours is associated with significant acute and long-term vascular toxicity, including life-threatening large artery vascular disease.
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Alerts clinicians to possible acute vascular events with VBP; leaves open true incidence and causality in germ cell tumors.
Samuels et al. (1987) studied this question.
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