Key result
Development of in-hospital heart failure with preserved ejection fraction in STEMI patients independently increased the risk of 8-year mortality compared to patients without heart failure.
Why the study?
The study aimed to analyze eight-year mortality in patients with STEMI complicated by in-hospital HFpEF.
Does the development of in-hospital HFpEF predict 8-year mortality in STEMI patients treated with primary PCI?
Observational (n=3,260)
No
Does the development of in-hospital HFpEF predict 8-year mortality in STEMI patients treated with primary PCI?
The development of in-hospital HFpEF in STEMI patients treated with primary PCI is an independent predictor of long-term mortality, though its prognostic impact is weaker than that of HFrEF.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to elevated long-term risk without guiding therapy; leaves open whether targeted interventions improve STEMI outcomes.
BACKGROUND/AIM: We aimed to analyze eight-year mortality in patients with ST-elevation myocardial infarction (STEMI) complicated by the development of in-hospital heart failure with preserved ejection fraction (HFpEF). METHOD: We analyzed 3260 STEMI patients treated with primary PCI (pPCI). Reduced EF was defined as value <50% and preserved EF as value ≥50%. Patients were divided in three groups: without HF, with HFpEF, and with HF with reduced EF (HFrEF). Patients with cardiogenic shock at admission were excluded. In the Cox regression model, HFpEF and HFrEF were independent predictors for 8-year mortality-HFpEF: HR1.85 (95%CI 1.26-4.25); HFrEF: 4.89 (95%CI 3.19-6.42). CONCLUSION: Development of in-hospital HFpEF in STEMI patients was an independent predictor for long-term mortality. The negative prognostic impact of HFpEF was weaker when compared to the impact of in-hospital HFrEF.
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Savić et al. (2025) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=3,260). In-hospital heart failure with preserved ejection fraction (HFpEF) vs. Without heart failure was evaluated on 8-year all-cause mortality (HR 1.85, 95% CI 1.26-4.25, p=0.012). Development of in-hospital heart failure with preserved ejection fraction in STEMI patients independently increased the risk of 8-year mortality compared to patients without heart failure.
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