Key result
Pre-existing conditions (hypertension, diabetes, obesity, multiple gestation) accounted for 22.3% (95% CI 19.8-24.9) of preeclampsia cases in nulliparous and 52.2% in multiparous women.
Why the study?
What is the population attributable fraction of severe or early preeclampsia associated with pre-existing conditions in nulliparous and multiparous women?
Population
70,924 women in the Danish National Birth Cohort (nulliparous and multiparous)
Comparison
Pre-existing conditions vs Women without these pre-existing conditions
Design
Cohort
Authors
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Pre-existing conditions may contribute substantially to preeclampsia risk; leaves open whether targeted modification reduces incidence pending interventional trials.
Cohort (n=70,924)
Yes
What is the population attributable fraction of severe or early preeclampsia associated with pre-existing conditions in nulliparous and multiparous women?
Pre-existing maternal conditions, including obesity and overweight, contribute to a high proportion of severe or early preeclampsia cases, highlighting the importance of managing these risk factors.
Catov et al. (2007) conducted a cohort in Preeclampsia (n=70,924). Pre-existing conditions (hypertension, diabetes, obesity, multiple gestation) was evaluated on Population attributable fractions of severe or early preeclampsia associated with pre-existing conditions. Pre-existing conditions (hypertension, diabetes, obesity, multiple gestation) accounted for 22.3% (95% CI 19.8-24.9) of preeclampsia cases in nulliparous and 52.2% in multiparous women.