Key result
Tissue Doppler echocardiography detected significantly lower systolic strain-rate in systemic sclerosis patients compared to matched controls (1.7 vs 3.8 cm-1, p<0.0001).
Why the study?
Does Tissue Doppler echocardiography detect early myocardial contractility alterations in systemic sclerosis patients with normal LVEF compared to matched controls?
Population
17 consecutive systemic sclerosis patients with normal cardiac examination, pulmonary artery pressure, and…
Comparison
Tissue Doppler echocardiography and… vs 15 matched healthy controls
Design
Case-control
Authors
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Tissue Doppler may detect subclinical systolic impairment in systemic sclerosis with normal LVEF; challenges conventional assessment consensus but leaves clinical adoption open.
Case-Control (n=32)
Does Tissue Doppler echocardiography detect early myocardial contractility alterations in systemic sclerosis patients with normal LVEF compared to matched controls?
Absolute Event Rate: 1.7% vs 3.8%
p-value: p=<0.0001
Tissue Doppler echocardiography can detect early subclinical myocardial contractility impairment in systemic sclerosis patients who have normal left ventricular ejection fraction by conventional methods.
Meune et al. (2005) conducted a case-control in Systemic sclerosis (n=32). Systemic sclerosis vs. Matched controls was evaluated on Systolic strain-rate (SR) measured in the posterior wall by TDE (p=<0.0001). Tissue Doppler echocardiography detected significantly lower systolic strain-rate in systemic sclerosis patients compared to matched controls (1.7 vs 3.8 cm-1, p<0.0001).
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