Key result
Oral nicardipine significantly increased mean left ventricular ejection fraction from 65.4% at baseline to 71.3% at 90 minutes in patients with systemic sclerosis (p<0.005).
Why the study?
Does oral nicardipine improve left ventricular function in patients with systemic sclerosis?
Population
20 patients with systemic sclerosis
Comparison
Nicardipine 40 mg oral single dose vs Baseline (pre-treatment)
Design
Case_series
Follow-up
90 min
Authors
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Should not change practice in systemic sclerosis; hypothesis-generating for nicardipine effects on LV function.
Does oral nicardipine improve left ventricular function in patients with systemic sclerosis?
Absolute Event Rate: 71.3% vs 65.4%
p-value: p=<0.005
A single 40 mg oral dose of nicardipine acutely improves left ventricular ejection fraction and regional wall motion in patients with systemic sclerosis.
Kahan et al. (1990) studied Systemic sclerosis (n=20). Nicardipine vs. Baseline was evaluated on Left ventricular ejection fraction (p=<0.005). Oral nicardipine significantly increased mean left ventricular ejection fraction from 65.4% at baseline to 71.3% at 90 minutes in patients with systemic sclerosis (p<0.005).
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