Raised blood pressure and plasma noradrenaline concentrations in teenagers and young adults selected from an open population.
Key result
Hypertensive teenagers and young adults had significantly higher plasma noradrenaline concentrations (351 pg/ml) compared with age-matched controls (248 pg/ml).
Why the study?
Are plasma noradrenaline concentrations elevated in teenagers and young adults with raised blood pressure compared to normotensive controls?
Population
77 teenagers and young adults, comprising 38 subjects with an initial blood pressure reading of ≥140/90 mm…
Design
Case-control
Follow-up
2 to 4 years
Authors
Discussion
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Implication
May implicate sympathetic overactivity in early hypertension; hypothesis-generating, should not yet change practice.
Study Design
Type
Case-Control (n=77)
Structured PICO
Are plasma noradrenaline concentrations elevated in teenagers and young adults with raised blood pressure compared to normotensive controls?
P
Population
77 teenagers and young adults (aged 13-23), comprising 38 subjects with an initial blood pressure reading of ≥140/90 mm Hg and 39 age-matched controls from the same open population.
C
Comparator
Age-matched normotensive controls
O
Outcome
Plasma noradrenaline (PNA) concentrationssurrogate
Main Result
Absolute Event Rate: 351% vs 248%
Elevated plasma noradrenaline concentrations in young hypertensive subjects suggest that increased sympathetic nervous system activity may play a role in early-onset hypertension.
Cite This Study
Hofman et al. (1979) conducted a case-control in Hypertension (n=77). Hypertension vs. Age-matched normotensive controls was evaluated on Plasma noradrenaline (PNA) concentrations. Hypertensive teenagers and young adults had significantly higher plasma noradrenaline concentrations (351 pg/ml) compared with age-matched controls (248 pg/ml).