Why the study?
Does losartan reduce cough incidence compared to lisinopril or hydrochlorothiazide in hypertensive patients with a history of ACE inhibitor-related cough?
Population
135 patients with uncomplicated primary hypertension with a history of ACE inhibitor-related cough…
Comparison
Losartan 50 mg once a day for 8 weeks vs Lisinopril 20 mg once a day or…
Design
RCT, randomly assigned, double-blind
Follow-up
8 weeks
Authors
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May support preferring losartan or HCTZ over lisinopril after ACEI cough; confirms lower cough rates with ARBs in this population.
Does losartan reduce cough incidence compared to lisinopril or hydrochlorothiazide in hypertensive patients with a history of ACE inhibitor-related cough?
Losartan causes significantly less cough than lisinopril, comparable to hydrochlorothiazide, in hypertensive patients with prior ACE inhibitor-induced cough.
re et al. (1994) studied this question.
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