Why the study?
Does losartan reduce the incidence of cough compared to lisinopril and metolazone in elderly hypertensive patients with previous ACE inhibitor-induced cough?
Population
84 elderly nonsmoking patients with hypertension and a confirmed history of ACE inhibitor-induced cough.
Comparison
Losartan 50 mg oral once daily for a maximum of… vs Lisinopril 10 mg once daily or metolazone 1 mg…
Design
RCT, Randomized, stratified, parallel-group, Double-blind
Follow-up
maximum of 10 weeks
Authors
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Supports losartan over lisinopril for prior ACE inhibitor cough; reinforces ARBs as preferred in ACEI-intolerant hypertension.
Does losartan reduce the incidence of cough compared to lisinopril and metolazone in elderly hypertensive patients with previous ACE inhibitor-induced cough?
Losartan provides an effective alternative for blood pressure management with a significantly lower incidence of cough compared to lisinopril in patients with a history of ACE inhibitor-induced cough.
Chan et al. (1997) studied this question.
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