Why the study?
Does valsartan reduce the incidence of cough compared to lisinopril or hydrochlorothiazide in adult outpatients with essential hypertension and a history of ACE inhibitor-induced cough?
Population
129 adult outpatients with essential hypertension and a history of angiotensin-converting enzyme…
Comparison
Valsartan 80 mg once daily for 6 weeks vs Lisinopril 10 mg once daily or…
Design
RCT, randomized, parallel group, double-blind
Follow-up
6 weeks
Authors
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Supports valsartan over lisinopril to minimize cough in ACEI-intolerant hypertensives; reinforces ARB preference in patients with prior ACE inhibitor cough.
Does valsartan reduce the incidence of cough compared to lisinopril or hydrochlorothiazide in adult outpatients with essential hypertension and a history of ACE inhibitor-induced cough?
In hypertensive patients with a history of ACE inhibitor-induced cough, valsartan provides comparable blood pressure reduction to lisinopril but with a significantly lower incidence of cough, similar to hydrochlorothiazide.
Benz et al. (1997) studied this question.
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