Key result
Descending aortic occlusion with whole-body cooling enabled robust whole-heart viral transfection in mice, restoring phospholamban protein and cardiac function in PLB-null mice at 3 months.
Descending aortic occlusion with whole-body cooling enables robust in vivo viral gene transfer to the murine heart, allowing for stable expression and functional restoration of proteins like phospholamban.
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Supports preclinical cardiac gene therapy testing in mice; leaves open clinical translation of this delivery approach.
Champion et al. (2003) studied Viral gene transfer to the murine heart. Descending aortic occlusion with whole-body cooling (20 degrees C) for viral gene transfer vs. Wild-type controls was evaluated on Cardiac transfection and restoration of PLB protein and function. Descending aortic occlusion with whole-body cooling enabled robust whole-heart viral transfection in mice, restoring phospholamban protein and cardiac function in PLB-null mice at 3 months.
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