Key result
High Field ex vivo MRI accurately quantified total fibrosis, interstitial fibrosis, fatty fibrosis, and fat in human left atrial myocardium, demonstrating high correlation with histology (r = 0.93 for total fibrosis).
Why the study?
Does ex vivo 4.0 T MRI accurately quantify fibrosis, fat, and fatty fibrosis in human left atrial myocardium compared to histology?
Case-Control (n=5)
Blinded analysis
No
Does ex vivo 4.0 T MRI accurately quantify fibrosis, fat, and fatty fibrosis in human left atrial myocardium compared to histology?
Effect estimate: r = 0.93
p-value: p=0.0007
High-field ex vivo MRI can accurately quantify total, interstitial, and fatty fibrosis as well as fat in human left atrial myocardium, showing excellent agreement with histological analysis.
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Supports ex vivo high-field MRI for atrial fibrosis research; leaves open in vivo validation and clinical translation.
Bouazizi et al. (2018) conducted a case-control in Mitral regurgitation or refractory heart failure (n=5). ex vivo MRI (T1 mapping and DIXON imaging) vs. Histology was evaluated on Correlation between MRI and histology for total fibrosis fraction (r = 0.93, p=0.0007). High Field ex vivo MRI accurately quantified total fibrosis, interstitial fibrosis, fatty fibrosis, and fat in human left atrial myocardium, demonstrating high correlation with histology (r = 0.93 for total fibrosis).
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