Key result
The ACE DD genotype was significantly associated with hypertensive crisis compared to healthy controls (38.5% vs 28.0%; OR 1.61; 95% CI 1.03-2.50; P=0.03), particularly in men.
Why the study?
Is the ACE DD genotype associated with an increased risk of hypertensive crisis in patients with essential hypertension?
Case-Control (n=364)
No
Is the ACE DD genotype associated with an increased risk of hypertensive crisis in patients with essential hypertension?
Effect estimate: OR 1.61 (95% CI 1.03-2.50)
Absolute Event Rate: 38.5% vs 28%
p-value: p=0.03
The ACE DD genotype is associated with an increased risk of hypertensive crisis, particularly in men.
ACE DD genotype may flag higher hypertensive crisis risk in men; hypothesis-generating and requires prospective validation before any clinical use.
OBJECTIVE: The genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis. DESIGN: Population-based case-control study. SETTING: Emergency department at a tertiary care university hospital. PATIENTS: A total of 182 patients with essential hypertension who were admitted to an emergency department for treatment of hypertensive crisis and 182 age- and sex-matched healthy individuals. INTERVENTIONS: None. MEASUREMENTS: Analysis of polymorphisms in genes coding for angiotensinogen (AJT 704T-->C), angiotensin II receptor 1 (AGTR1 1166A-->C), renin (REN 2646G-->A), renin-binding protein (RENBP 61T-->C), alpha-adducin (ADD1 1378G-->T), beta-2-adrenergic receptor (ADRB2 46A-->G, 79C-->G), and angiotensin I converting enzyme (ACE I/D) was performed by polymerase chain reaction and restriction fragment length polymorphism analysis. MAIN RESULTS Among patients, the ACE I/D polymorphism showed a deviation from Hardy-Weinberg equilibrium (p =.01). In controls, all polymorphisms were in the Hardy-Weinberg equilibrium. The frequency of the DD genotype was increased in patients (n = 70, 38.5%) vs. controls (n = 51; 28.0%;p =.03; odds ratio, 1.61; 95% confidence interval, 1.03-2.50), which was due to the DD genotype in 40 male patients (44%) vs. 23 in male controls (25.3%;p =.004; odds ratio, 3.48; 95% confidence interval, 1.47-8.30). There were no differences in genotype distributions among other polymorphisms. CONCLUSION: We demonstrate a possible association of the DD genotype with hypertensive crisis in men.
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Sunder‐Plassmann et al. (2002) conducted a case-control in Hypertensive crisis (n=364). ACE DD genotype vs. Healthy controls was evaluated on Presence of ACE DD genotype (OR 1.61, 95% CI 1.03-2.50, p=0.03). The ACE DD genotype was significantly associated with hypertensive crisis compared to healthy controls (38.5% vs 28.0%; OR 1.61; 95% CI 1.03-2.50; P=0.03), particularly in men.
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