Key result
Nitroprusside infusion increased total vascular volume to 111% of control (p<0.01), with the absolute increase in venous volume being almost 4 times greater than the arterial increase.
Why the study?
Does nitroprusside infusion differentially affect arterial versus venous vascular capacitance in a canine ileal model?
Does nitroprusside infusion differentially affect arterial versus venous vascular capacitance in a canine ileal model?
p-value: p=<0.01
Nitroprusside increases both arterial and venous capacitance, but the absolute increase in venous volume is much larger due to its greater baseline capacity.
Authors
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Nitroprusside's greater venous capacitance effect in canine ileal models warrants clinical caution; extends two-compartment capacitance data but leaves human translation open.
Wang et al. (1999) studied this question. Nitroprusside vs. Control (baseline) was evaluated on Total vascular volume (p=<0.01). Nitroprusside infusion increased total vascular volume to 111% of control (p<0.01), with the absolute increase in venous volume being almost 4 times greater than the arterial increase.
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