Why the study?
Intensive systolic blood pressure lowering is increasingly used, but data are missing on patients who achieve their target blood pressure.
Does achieving an intensive SBP target (110 to <130 mmHg) reduce cardiovascular events compared to achieving a standard SBP target (130 to <150 mmHg) in hypertensive patients aged 60-80 years?
Population
8511 hypertensive patients aged 60-80 years without prior stroke
Comparison
Intensive treatment (SBP target 110 to <130 mmHg) vs standard treatment (130 to <150 mmHg)
Design
Secondary analysis of a multicentre randomized controlled trial
Follow-up
Median 3.38-year
Key result
Maintaining systolic blood pressure at intensive levels (<130 mmHg) significantly lowered cardiovascular risk compared to standard treatment (HR 0.61; 95% CI 0.46-0.80; P<0.001).
Authors
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Supports intensive SBP targets (<130 mmHg) in hypertensives aged 60-80; reinforces benefits from prior randomized trials.
RCT (n=8,511)
Yes
Does achieving an intensive SBP target (110 to <130 mmHg) reduce cardiovascular events compared to achieving a standard SBP target (130 to <150 mmHg) in hypertensive patients aged 60-80 years?
Effect estimate: HR 0.61 (95% CI 0.46-0.80)
p-value: p=< 0.001
Achieving and maintaining an intensive SBP target of <130 mmHg provides significant cardiovascular benefits over standard targets in older hypertensive patients.
Deng et al. (2023) conducted an RCT in Hypertension (n=8,511). Intensive SBP lowering (target 110 to <130 mmHg) vs. Standard SBP lowering (target 130 to <150 mmHg) was evaluated on Cardiovascular events (HR 0.61, 95% CI 0.46-0.80, p=< 0.001). Maintaining systolic blood pressure at intensive levels (<130 mmHg) significantly lowered cardiovascular risk compared to standard treatment (HR 0.61; 95% CI 0.46-0.80; P<0.001).