What does this research mean for the field?

Ischaemic preconditioning alters coronary reactive hyperaemia by decreasing total hyperaemic flow via A1 adenosine receptor activation and reducing time to peak flow via increased endothelial nitric oxide release. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1999Cardiovascular ResearchOpen Access

Ischaemic preconditioning changes the pattern of coronary reactive hyperaemia in the goat: role of adenosine and nitric oxide

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Why the study?

Does ischaemic preconditioning alter coronary reactive hyperaemia through A1 adenosine receptors and nitric oxide in anaesthetised goats?

Structured PICO

Does ischaemic preconditioning alter coronary reactive hyperaemia through A1 adenosine receptors and nitric oxide in anaesthetised goats?

Population

Anaesthetised goats (n=21)

Intervention

Ischaemic preconditioning (two episodes of 2.5 min coronary occlusion separated by 5 min reperfusion) with or without A1 receptor blockade (8-cyclopentyl-dipropylxanthine 0.2 mg kg-1) or NO inhibition (NG-nitro-L-arginine 10 mg kg-1)

Comparator

Reactive hyperaemia before ischaemic preconditioning

Outcome

Changes in coronary reactive hyperaemia (time to peak hyperaemic flow and total hyperaemic flow)surrogate

Ischaemic preconditioning alters coronary reactive hyperaemia by decreasing total hyperaemic flow via A1 receptors and reducing time to peak flow via endothelial nitric oxide release.

Discussion

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Implication

Supports A1/NO mediation of preconditioning effects on coronary hyperaemia in goats; hypothesis-generating for human translation.

Cite This Study

D Gattullo (1999) studied this question.

synapsesocial.com/papers/6a1886c61ca866914fc9bf36 https://doi.org/10.1016/s0008-6363(98)00319-8

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