What does this research mean for the field?

During salt restriction, the increased activity of the renin-angiotensin system exerts approximately equivalent vasoconstrictor influences on both preglomerular and postglomerular vascular resistance elements. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1982HypertensionOpen Access

Influence of converting enzyme inhibition on renal hemodynamics and glomerular dynamics in sodium-restricted dogs.

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Why the study?

Does converting enzyme inhibition alter renal hemodynamics and glomerular dynamics in sodium-restricted dogs?

Population

Anesthetized sodium-restricted dogs (n=25)

Comparison

Converting enzyme inhibition (CEI) with SQ 14,225 vs Baseline measurements before CEI and control…

Design

Preclinical

Authors

LNL. Gabriel NavarVascular Medicine DJDusit JirakulsomchokKhon Kaen University PBP. Darwin BellUniversity of Alabama at Birmingham

Discussion

Member takes

Implication

CEI effects on renal hemodynamics in sodium-restricted dogs should not change practice; leaves open translation to human hypertension.

Structured PICO

Does converting enzyme inhibition alter renal hemodynamics and glomerular dynamics in sodium-restricted dogs?

Population

Anesthetized sodium-restricted dogs (n=25)

Intervention

Converting enzyme inhibition (CEI) with SQ 14,225

Comparator

Baseline measurements before CEI and control dogs (n=5) subjected to the same procedures

Outcome

Renal hemodynamics (renal blood flow, glomerular filtration rate) and segmental vascular resistancessurrogate

Converting enzyme inhibition in sodium-restricted dogs increases renal blood flow and GFR by reducing both preglomerular and postglomerular vascular resistance.

Cite This Study

Navar et al. (1982) studied this question.

synapsesocial.com/papers/6a188f88a61bfdbaa2c9c71d https://doi.org/10.1161/01.hyp.4.1.58

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January 1, 1982HypertensionOpen Access

Influence of converting enzyme inhibition on renal hemodynamics and glomerular dynamics in sodium-restricted dogs.

View Full Paper

Ask AI

Bookmark

Why the study?

Does converting enzyme inhibition alter renal hemodynamics and glomerular dynamics in sodium-restricted dogs?

Population

Anesthetized sodium-restricted dogs (n=25)

Comparison

Converting enzyme inhibition (CEI) with SQ 14,225 vs Baseline measurements before CEI and control…

Design

Preclinical

Authors

LNL. Gabriel NavarVascular Medicine DJDusit JirakulsomchokKhon Kaen University PBP. Darwin BellUniversity of Alabama at Birmingham

Discussion

Member takes

Implication

CEI effects on renal hemodynamics in sodium-restricted dogs should not change practice; leaves open translation to human hypertension.

Structured PICO

Does converting enzyme inhibition alter renal hemodynamics and glomerular dynamics in sodium-restricted dogs?

Population

Anesthetized sodium-restricted dogs (n=25)

Intervention

Converting enzyme inhibition (CEI) with SQ 14,225

Comparator

Baseline measurements before CEI and control dogs (n=5) subjected to the same procedures

Outcome

Renal hemodynamics (renal blood flow, glomerular filtration rate) and segmental vascular resistancessurrogate

Converting enzyme inhibition in sodium-restricted dogs increases renal blood flow and GFR by reducing both preglomerular and postglomerular vascular resistance.

Cite This Study

Navar et al. (1982) studied this question.

synapsesocial.com/papers/6a188f88a61bfdbaa2c9c71d https://doi.org/10.1161/01.hyp.4.1.58

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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