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Hypothesis-generating for angiotensin-independent renal autoregulation; requires validation before clinical translation.
SummaryThe role of the renin-angiotensin system in the autoregulation of renal blood flow and glomerular filtration rate was examined in the dog. The angiotensin converting enzyme inhibitor, SQ20881, was continuously infused into one renal artery during a reduction in renal perfusion pressure to both kidneys. Renal autoregulation was maintained in the infused kidney despite the continuous infusion of a dose of SQ20881 which was shown to completely reverse the renal hemodynamic effects of exogenously administered angiotensin I in a second group of experiments.
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Gagnon et al. (1974) studied this question.
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