Why the study?
Does intrarenally formed angiotensin II control glomerular filtration rate during reduction of renal artery pressure in dogs?
Population
Dogs with only a functional intrarenal renin-angiotensin system (RAS)
Comparison
Blockade of intrarenal ANG II formation with SQ… vs Control state prior to SQ 14225 infusion
Design
Preclinical
Authors
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Intrarenal ANG II supports canine GFR autoregulation during RAP reduction; leaves open translation to human physiology.
Does intrarenally formed angiotensin II control glomerular filtration rate during reduction of renal artery pressure in dogs?
Intrarenal angiotensin II formation plays an important role in maintaining glomerular filtration rate during reductions in renal artery pressure by constricting efferent arterioles.
Kastner et al. (1984) studied this question.
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