Population
Anesthetized rats maintained for 3-5 weeks on low, normal, or high salt plus deoxycorticosterone diets
Comparison
Intravenous administration of angiotensin I… vs Base-line observations before inhibition
Design
Preclinical
Authors
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RAS not essential for RBF autoregulation in rats; leaves open translation to human salt-sensitive hemodynamics.
The renin-angiotensin system modifies baseline renal blood flow but is not an essential mechanism for its autoregulation in rats.
Arendshorst et al. (1977) studied this question.
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