Why the study?
Does thromboxane synthesis inhibition or receptor blockade improve renal function in rats with angiotensin II-salt-induced hypertension?
Population
Rats with angiotensin II-salt hypertension
Comparison
UK 38,485 or SQ 29,548 vs Water- and saline-drinking normotensive rats…
Design
Preclinical
Follow-up
12 days
Authors
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TxA2 receptor blockade may selectively affect renal hemodynamics in this model; leaves open translation to human hypertension.
Does thromboxane synthesis inhibition or receptor blockade improve renal function in rats with angiotensin II-salt-induced hypertension?
Pressor eicosanoids like TxA2 and prostaglandin endoperoxides contribute to increased renal vascular resistance in severe Ang II-salt hypertension.
Mistry et al. (1990) studied this question.
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