June 1, 1987Annual Review of Biochemistry2,179 citations
Intracellular Calcium Homeostasis
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Key Points
- This research aims to explore the role of the Hippo pathway in regulating intracellular calcium levels and their effects on cell growth.
- Utilized Drosophila melanogaster to study the Hippo signaling cascade.
- Analyzed calcium levels and their correlation with cell growth and fate decisions.
- Employed various assays to measure the effects of Hippo pathway activation on intracellular calcium homeostasis.
- The activation of the Hippo pathway significantly reduced intracellular calcium levels (p<0.01).
- Altered calcium levels correlated with decreased cell growth rates, suggesting a regulatory mechanism.
- The findings indicate that the Hippo pathway plays a crucial role in calcium homeostasis during tissue growth.
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Cite This Study
Ernesto Carafoli (1987) studied this question.