Key result
Tropomodulin1 knockout in mice leads to aborted heart development, failure of myofibril maturation, and embryonic lethality by embryonic day 10.5.
Tmod1 is essential for the regulation of actin filament lengths and myofibril maturation, which is critical for embryonic heart morphogenesis and survival.
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Should not change clinical practice; hypothesis-generating for Tmod1 in mammalian cardiogenesis.
Fritz-Six et al. (2003) studied Heart development. Tmod1 knockout was evaluated on Myofibril assembly and heart development. Tropomodulin1 knockout in mice leads to aborted heart development, failure of myofibril maturation, and embryonic lethality by embryonic day 10.5.
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