Population
Rabbit reticulocyte extracts and HeLa cells infected with encephalomyocarditis virus (EMC)
Design
Preclinical
Authors
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Offers in vitro tool for picornavirus protease studies; leaves open in vivo validation and relevance.
This study demonstrates a method for efficient cell-free expression of cloned viral gene segments and identifies 3C protease as the enzyme responsible for cleavage between the leader peptide and capsid protein VP0 in encephalomyocarditis virus.
Parks et al. (1986) studied this question.
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