Population
in vitro cell-free protease assays using cDNA clones expressing genetically altered forms of the…
Comparison
Site-specific substitutions introduced into the… vs Free enzyme (3C) and normal cleavage site contexts
Design
Preclinical
Authors
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3C precursors may mediate EMCV maturation equivalently to free enzyme; leaves open whether cleavage specificity guides future antiviral strategies.
Encephalomyocarditis virus P3 region precursor proteins are as active as the free 3C enzyme in processing capsid substrates, and the enzyme exhibits specific amino acid pair cleavage preferences.
Parks et al. (1989) studied this question.
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