Key result
Metabolic syndrome drives HF development and progression via visceral adiposity, chronic inflammation, and insulin resistance.
Why the study?
Heart failure and metabolic syndrome affect a large proportion of the world population, with metabolic syndrome serving as both a risk factor and comorbidity for heart failure.
Comprehensive management of metabolic syndrome components, including visceral adiposity, hypertension, and insulin resistance, is crucial for preventing heart failure and improving outcomes in patients with established heart failure.
Answers are grounded in this paper and cite their sources.
May support metabolic syndrome management in heart failure care; leaves open prospective trials to confirm causality and guide practice.
Heart failure (HF) and metabolic syndrome (MetS) are syndromes that affect a large proportion of the world population. MetS is known to be one of the risk factors of HF, and it can also act as comorbidity in HF. This review aims to further discuss the mechanism of MetS in causing HF, the management of MetS in order to prevent HF, and the management of MetS in HF patients. Visceral adiposity is the primary trigger of MetS which is followed by chronic inflammation, insulin resistance, and neurohormonal activation. All the mechanisms causing MetS play also an important role in the progression of HF. The MetS approach can be achieved by managing its components according to the current guidelines and careful management of MetS should be done in patients with HF. MetS is closely related to the progression of HF so that comprehensive management which involves a multidisciplinary team is necessary for managing patients with metabolic syndrome and heart failure.
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Purwowiyoto et al. (2021) conducted a review in Metabolic syndrome and heart failure. Metabolic syndrome is closely related to the development and progression of heart failure, primarily triggered by visceral adiposity, chronic inflammation, insulin resistance, and neurohormonal activation.
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