Key result
Drug treatment of hypertension may significantly decrease systolic and diastolic blood pressure while leaving pulse pressure unchanged, potentially maintaining cardiovascular risk.
Why the study?
Does drug treatment of hypertension reduce mean blood pressure and pulse pressure in parallel with systolic and diastolic blood pressure?
Does drug treatment of hypertension reduce mean blood pressure and pulse pressure in parallel with systolic and diastolic blood pressure?
Antihypertensive therapy may fail to reduce pulse pressure despite lowering systolic and diastolic blood pressure, potentially leaving residual cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Antihypertensives may leave pulse pressure and residual CV risk unchanged; leaves open whether pulse pressure-specific targets improve outcomes.
Drug treatment of hypertension reduces systolic and diastolic blood pressure according to a well-established dose-response curve. Whether there is a parallel decrease in mean blood pressure and pulse pressure has not been investigated in the past Recent analysis of the literature and personal work indicates that, during drug treatment of hypertension, a significant decrease in systolic and diastolic blood pressure may be associated with an unchanged pulse pressure, a situation that might contribute to maintaining cardiovascular risk.
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Safar et al. (2000) conducted a review in Hypertension. Drug treatment was evaluated on Blood pressure and pulse pressure. Drug treatment of hypertension may significantly decrease systolic and diastolic blood pressure while leaving pulse pressure unchanged, potentially maintaining cardiovascular risk.
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