March 1, 1996ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
Vascular Smooth Muscle Polyploidy and Cardiac Hypertrophy in Genetic Hypertension
Population
F2 generation of a cross between stroke-prone spontaneously hypertensive rats and normotensive Wistar-Kyoto…
Design
Preclinical
Authors
Discussion
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Implication
Should not change practice; leaves open translation of angiotensin II suppression to human vascular and cardiac remodeling.
Structured PICO
P
Population
F2 generation of a cross between stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats, and 8-week-old SHRSP
I
Intervention
Perindopril, losartan, or perindopril combined with N(G)-nitro-L-arginine methyl ester
O
Outcome
Vascular smooth muscle polyploidy and cardiac hypertrophy (ratios of heart weight to body weight and left ventricle + septum weight to body weight)surrogate
Suppression of angiotensin II lessens both vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension models, despite differing regulatory variables.
Cite This Study
Dominiczak et al. (1996) studied this question.