Why the study?
Do incremental increases in negative intrathoracic pressure reduce left ventricular stroke volume in healthy humans?
Do incremental increases in negative intrathoracic pressure reduce left ventricular stroke volume in healthy humans?
In healthy supine humans, negative intrathoracic pressure of -20 cmH2O or greater significantly reduces left ventricular stroke volume due to direct ventricular interaction and increased afterload.
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Negative intrathoracic pressure ≥−20 cmH₂O may reduce LVSV in healthy subjects; hypothesis-generating for disease states.
Cheyne et al. (2018) studied this question.
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