In slow-twitch rat skeletal muscle during dynamic activity, sustained slower contraction velocities and decreased muscle shortening may be driven by dephosphorylation of the regulatory myosin light chain (MLC2s) rather than purely metabolic changes.
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Implicates MLC2 dephosphorylation in sustained contractile slowing during fatigue; leaves open translation to human cardiac or skeletal muscle.
Munkvik et al. (2009) studied this question.
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